Diagnostic and prognostic significance of placenta genetic expression profile change against preeclampsia background is highlighted. It is established that hypoxia, apoptosis, angiogenesis and folates metabolism belong to basic pathologic mechanisms. The important etiopathogenetic factor of preeclampsia progressing is increasing of fetal hemoglobin content in the maternal blood plasma, which as a biomarker can be used in the II and III trimesters of the pregnancy.
