Objective: studying of development and distribution of apoptosis markers р53, bcl-2 and proliferation Кі67 in endometrium at hyperplasia processes and definition of their importance in future therapeutic or surgical management.
Materials and methods. It was done histologic and immunohistochemical investigation of endometrium at 71 women. The main group costisted of 57 women with hyperplasia of endometrium and adenocarcinoma (11 — simple hyperplasia without atypia, 18 — complex hyperplasia without atypia, 15 — complex hyperplasia with atypia, 8 — adenocarcinoma), the control group consists of 14 patients with morphological unchanged endometrium (proliferation stage — n=6, secretion stage — n=8). Using immunohistiochemical methods we defined apoptosis markers expression — p53, bcl-2 and proliferation markers Кі67 in epithelial and stromal endometrium cells.
Results and discussion. We have defined that expression of apoptosis markers р53 end bcl-2 in epithelial cells was increased at complex atypical hyperplasia. We have observed all these changes with the tendency to proliferation marker Кі67 increasing, that indicates changes in process of apoptosis and proliferation correlation in atypia process development.
Conclusions. Choosing therapeutic or surgical management we have to know the histological condition of endometrium especial the intensivity and the stage of protein р53, bcl-2 and Ki67 expression.