Actuality. An actual problem of modern hematology is the diagnosis and treatment of chronic lymphoid leukemia (CLL). Despite the fact that a great number of new groups of anticancer drugs have recently appeared, the foundation of most CLL chemotherapy regimes in Ukraine, as before, are alkylating agents CHOP-therapy (cyclophosphamide, doxorubicin, vincristine and prednisolone), which are often toxic. The most effective and the one that causes the least serious adverse events are considered combination with fludarabine and cyclophosphamide (FC-therapy).
The main task of the study was to investigate the levels of alpha-1-acid glycoprotein (AGP), fibronectin (FN) and their correlation with biochemical parameters in plasma of patients with chronic lymphoid leukemia before treatment and after the first course of chemotherapy with CHOP and FC.
Materials and Methods. In the blood of patients with CLL the fibronectin level reduces by (30.5±3.0)% and the alpha-1-acid glycoprotein level increases by (30.9±1.8)%. Under the influence of CHOP-therapy ALT, platelet count and the level of fibronectin increased, and the content of alpha-1-acid glycoprotein reduced by (35.2±2.2)%. After the FC-treatment the number of leukocytes and AGP reduced significantly, but fibronectin level remained unchanged. Coefficient of ratio FN/AGP in plasma of CLL patients before treatment was 0.25 and was to the control values at CHOP-therapy. Coefficient of ratio FN/AGP in plasma is doubled when FC-therapy was used. FC-treatment was the most effective against reducing the number of leukocytes.
Results. Since the reducing tumor cells number is the major task in the treatment of patients with chronic lymphoid leukemia, the ratio FN/AGP can be used to evaluate the results of therapy.