ANALYSIS OF HYDAZEPAM ІC BIOPHARMACEUTICAL PROPERTIES

When using the official version of ADMET Predictor™ it was made prediction of some biopharmaceutical properties and metabolism of hidazepam. The main pharmacokinetic parameters of transit and drug absorption from the gastrointestinal tract with the official version of the program GastroPlus™ were calculated. The kinetics of release of the active pharmaceutical ingredient from the tablets of the two series, containing the auxiliary substance — povidone of different manufacturers in three buffer solutions in the pH range 1.2–6.8.