The questions of participation of the nitrogen oxide system were studied in forming of different links of pathogenic changes in ischemic stroke. On the model of irreversible bilateral occlusion of carotid arteries in rats in homogenate of brain on a background of Ronkoleukin (0.01 mg/kg) administration normalization of indexes of nitrogen oxide cycle (NO-synthase, nitrates, L-arginin), functional activity of mitochondria (membrane potential of mitochondria charge), energetic metabolism index, and also apoptosis normalization in the brain neurons was noted.
