One of the leading role in the professional pathology belongs to vibration disease (VD) at which the development of vascular and peripheral nervous system, musculoskeletal system, vestibular analyzer affection syndromes is possible. VD according to its frequency takes the second place among the peripheral nervous system diseases (after dust pathology of respiratory apparatus) among the workers of Ukrainian main industries. According to the data of numerous researches cardiovascular pathology is the leading comorbiduous state with professionally stipulated diseases. In the structure of accompanying cardiovascular diseases the hypertension disease (HD) is prevailed. Though, the bioelemental homeostasis which the patients with vibration disease in accordance with hypertension disease have, has been still poorly studied.
Aim. The research of the dynamics of minor and major mineral composition in blood serum with VD and HD patients.
Materials and methods of the research. It was included 107 patients with the vibration disease diagnosis of local vibration of the I and II stages, aged 41–66 (average age 54±6,17). Among them 60 patients had VD with HDII (the main group), and 47 patients had isolated VD (comparison group). The content of minor and major mineral elements (calcium, magnesium, zinc, copper, iron) was determined by atomic absorption method with a spectrophotometer “Saturn-4” (Russia).
Results and their discussion. It was detected the statistically important increase in Ca (р<0,001) in the comparison group as compared with the following group and also the accumulation of this figure at VD progressing. It’s also detected statistically important increase in Са (р<0,001) in the main group compared to the comparison and following groups. The level of Mg was statistically authentic (р<0,001) increasing in the comparison group compared to the following group. The level of Mg was increasing on VD progressing. Statistically authentic increase of Mg (р<0,001) in accordance with combined HD is evidently adoptation reaction aimed at the prevention of vasospastic reactions. It was also detected statistically important (р<0,001) increase of Zn connected with VD progressing. We also detected statistically authentic increase of Fe in the group with accompanied HD. In the course of the research it was detected a slight increase of Cu in blood serum with the patients with isolated VD. The content increase of Cu in blood serum can be also connected with the abnormality of transport protein synthesis in the liver against the background of vibration stipulated pathology of liver. The authentic increase of Cu in the main group was observed. Despite the fact that changes of biometals had multidirectional character, with the pathophysiological point of view these abnormalities can be determined as “syndrome of combined imbalance of biometals”.
Conclusions. The content of biometals in examined patients’ blood plasma in all groups was reliably higher than in the control group. The most significant differences were in the blood of patients suffering from vibration diseased with hypertension disease and they were increasing with pathology severity. The increase in the content of biometals in examined patients of all groups indicates the existence of common links in abnormalities of vascular tone regulation in VD and HD patients and indicates the active collaboration of examined minor mineral elements in these processes.