Introduction. Increase of dysmetabolic nephropathy rate with active stone formation is in structure of the urinary system diseases in children. As a result of metabolic processes imbalance under the influence of endogenous complex and exogenous factors, there is a progression of renal metabolic disturbances from crystalluria till nephrolithiasis.
Aim of the research was identifying the importance of the most typical and common for nephrolithiasis and dysmetabolic nephropathy clinical and anamnesis predictors with analysis of their role in the progression of metabolic disturbances and the development of predictive models.
Methods and subjects. The research was carried out with participation of 300 patients with diagnosed nephrolithiasis and dysmetabolic nephropathy at the age 3–25 years.
Results. There had been analyzed 78 factors. After mathematical analysis it was marked out 15 key predictors, including the availability of associated disease (respiratory, digestive and urinary systems, allergic disease), history data about repeated antibiotic therapy courses, burden heredity in diseases of the urinary pathology and metabolic disorders, disorders of intestinal biocenosis, peculiarity of diet and drinking regime.
The result of multinomial analysis confirms the unity of the pathogenic mechanisms in various stages of dysmetabolic nephropathy progression: from dysmetabolic nephropathy to nephrolithiasis.
Selfdescriptiveness combinations of symptoms, which are important for the progression of renal dysmetabolic processes, had been found with logistic regression method.
Conclusion. The predictive models of metabolic nephropathy were modelled. The presence of certain predictors’ combinations allows formulating conclusions about the evolution of dysmetabolic nephropathy.