Background. One of the considered factors of women cardiovascular disease at the menopause is the presence of metabolic syndrome (MetS), at the pathologic physiology of which the system of hemostasis. The aim of the study was to find out the concentration of fibrin(ogen), D-dimer and antibody level to cardiolipin within the ovariectomy rats with MetS and at the condition of administration of 17β-estradiol.
Methods. The research was conducted on the 3 month Wistar rats with ovariectomy. MetS induction was made by the way of long-lasting (during two months) administration of fructose with the drinking water at the concentration of 200 g per liter (high fructose diet). The 17β-estradiol was administrated in peroral way at the concentration 0,2 mg/kg of b.m. the first day of experiment.
Results. It has been shown that the deficit of estrogens causes the functional disorder of coagulation hemostasіs mechanisms that is proved by the concentration increase of fibrin(ogen), D-dimer and antibody to cardiolipin in the blood. The combination of hypoestrogenia with MetS causes the increase of hemocoagulation system disorders. The 17β-estradiol made normalizing influence on the concentration of analytes that can prove its positive influence to prevent the development of thrombogenic desorders at the conditions of metabolic syndrome with estrogens deficit.
Conclusions. The estrogens deficit is the independent reason to activate procoagulation link of hemostasis system. The combination of hypoestrogenia with MetS enforces the misbalance of coagulation hemostasis. The 17β-estradiol restrains hemocoagulation disorder manifestations.