SOME MECHANISMS OF ENDOTHELIOPROTECTIVE ACTION OF A NEW ORIGINAL DRUG LISINIY IN EXPERIMENTAL ISCHEMIC DAMAGE OF THE BRAIN

Results of the study of the endotheliotropic properties of the new original drug Lisiniy are presented in the article. It was shown that Lisiniy increases density, area of the nuclei of the IV–V cortical layers’ endotheliocytes and RNA content in them. Treatment of the experimental animals with Lisiniy leads to the increase of the endotheliocytes’ endothelial growth factor concentration and stimulates proliferate activity of the vascular endothelium in the brain.