Chronic heart failure is a major problem in modern medicine. Clinical course and prognosis of chronic heart failure is largely determined by the presence of concomitant anemic syndrome. Disturbances of iron metabolism is a frequent condition in patients with chronic heart failure with or without concomitant anemia.
The aim is to determine the structure of anemic syndrome by studying the level of transferrin saturation, ferritin, index transferrin/log ferritin and indicators of hemogram in patients with chronic heart failure of different functional class.
Materials and methods. The concentration of ferritin was determined by immunoassay. Transferrin saturation is defined as the ratio of serum iron to the level of transferrin. Transferrin/log ferritin index was calculated as the ratio of soluble transferrin receptor to the logarithm of ferritin.
Results. Our findings suggest about the heterogeneity of the structure of anemic syndrome in patients with chronic heart failure are associated with the redistribution of iron.
Conclusion. Presence of II functional class in patients with chronic heart failure is characterized by a predominance of symptoms of chronic disease anemia. Progression of cardiac decompensation is associated with combination of anemia of chronic disease and iron deficiency anemia, increase of percentage of patients with isolated iron deficiency anemia. Anemia as a result of hemodilution is observed in 8.6% of patients with IV functional class of chronic heart failure.