Urgency. Diseases of the oral mucous membrane (OMM) is an important problem of modern dentistry. A special attention is paid to the state of local and general factors of nonspecific and specific protection in pathogenesis of OMM diseases that substantiates the significance of local therapy, which is able to increase efficacy of the tissue protection against infections and regeneration.
The purpose of the study. To study the anti-inflammatory effect of the developed gel “Apident” in local application in complex therapy of patients with OMM diseases.
Materials and methods. There were examined 42 persons aged from 15 to 30 who were divided into 3 groups: I — the main group including patients with mechanic OMM trauma, in treatment of which the gel “Apident” was applied locally (14); II — the comparison group where treatment of patients with OMM diseases was given by traditional methods (13); III — control, dentally healthy people (15). There were analyzed the main clinical symptoms of the OMM state, biochemical studies of the inflammation markers, indices of microbial semination, activity of the antioxidant protection of the oral fluid of all patients during treatment.
Conclusions.
1. Local application of the developed gel “Apident” in complex treatment influences positively on dynamics of the clinical symptoms of OMM diseases having anti-inflammatory and analgesic effect.
2. The gel “Apident” decreases the degree of inflammation and dysbiosis in the oral cavity manifesting antimicrobial properties.
3. The application of the gel “Apident” increases nonspecific reactivity in the oral cavity at the expense of enzyme activation of the antioxidant protection.
4. The results obtained show perspective application of the new gel in treatment of erosive-ulcerous affections of OMM.