Introduction. Alterations in interaction between the systems of immunity and hemostasis have procoagulant nature and often lead to the development of intravascular coagulation process in patients with tuberculosis, that negatively affects the patients’ general state and the course of tuberculosis. The main goal of this research was to determine the hemostasis’ status in patients with tuberculosis before and two months after the inpatient treatment.
Materials and methods. Investigation of the hemostatic system was carried out in 225 patients using a standard coagulogram.
Results and discussion. Patients in the dynamics of the tuberculosis course showed destabilization of the hemostatic system, resulting in an increase of hypercoagulable markers. Some indicators showed a tendency to stabilization, which although do not correlate with the effectiveness of treatment and the patients condition regarding the hemostatic system. This situation is likely to be associated with the depletion of the pool of coagulation factors and accompanying liver disease, which is also exposed to hepatotoxic effects of antituberculous drugs.
Conclusions. Patients with tuberculosis before the treatment showed statistically significant increase in such important indicators as coagulation rate of spontaneous platelets’ aggregation, the activated partial thromboplastin time, prothrombin time, fibrinogen concentration and decrease in prothrombin index. After two months of inpatient treatment the patients showed increased intensification of the fibrin stabilizing factor activity, plasma recalcification time, clot retraction and blood activity fibrinolytic levels.
In dynamics this group of patients also showed moderate stabilization of prothrombin time, fibrinogen concentration and prothrombin index in comparison with the control group.