Introduction. Neurological hyperactive urinary bladder is often met in children with the prevalence in age of 5–7 when up to 20 % of total population is suffering from these disturbances. Such disturbances don’t answer the treatment and existing approaches are characterized by a number of side effects.
The aim of the research was to investigate effects of combined usage of dynamic neuro-electric stimulation (DNES) and M-cholynolytic therapy (driptan) upon manifestations of urinary bladder dysfunction (UBD) in children.
Methods of investigations. The severity of manifestations of UBD have been estimated in accordance to score system proposed by E. Vishnevsky Therefore three levels of severity have been defined (27 — highest, 49 — middle and 51 low level). Urodynamic inspection included uroflowmetry.
Results of investigations. Combined usage of DNES and M-cholynolytic in the group with highest level of disturbances caused the reduction of severity of urodynamic manifestations by 3.1 while separately given DNES and basic therapy were followed by 34.1 and 28.0% reduction correspondingly. Meanwhile, DNES and M-cholynolytic reduced severity in patients with pronounced disturbances by 7.5 times. Combined usage of M-cholynolytic and DNES in severely manifested UBD increased the effective volume of bladder by 2.3 times when compared with the pretreatment one, and separately given DNES and traditional treatment caused the increasing by 31.1% and 67.1% correspondingly. Also significant reduction of both intrabladder pressure (by 48.0%) and compliance of the bladder (4.8 times) were detected under condition of combined usage of DNES and M-cholynolytic. Both indices were modified to less extent in case of separate usage of DNES or M-cholynolytic when compared with that one registered after combined usage of those factors (P<0.05).
Conclusions. Obtained data confirm potentiation of effectiveness of combined usage of M-cholynolytic and DNES in patients suffered from hyperactive urinary bladder. Such combination was effective in patients suffered from severe form of disease while separate usage of M-cholynolytic and DNES were much less effective.