Mechanisms of anemia formation in patients with chronic heart failure and chronic kidney disease are poorly understood and controversial. Disruption of iron metabolism play a role in anemia development.
The aim of the study is to evaluate iron transport fund in patients with chronic heart failure and chronic kidney disease with anemia based on the study of the dynamics of transferrin and to study possible links with parameters of kidney function, immune inflammation based on the definition of proinflammatory cytokine interleukin-6.
Materials and methods. The concentration of interleukin-6, transferrin, albumin in urine were determined by immunoassay.
Results of studying the dynamics of transferrin in anemic patients with chronic heart failure and chronic kidney disease showed deep disturbances in the form of its serum concentrations reduction, which reflects the disturbances in iron transport fund.
Conclusion. Presence of anemia in patients with chronic heart failure and chronic kidney disease is characterized by impaired transport fund of iron, resulting in lowering serum levels of transferrin in study cohort. Microalbuminuria and high activity of immune inflammation, presented by interleukin-6, have negative synergistic action aimed at iron transport fund, represented by transferrin, in patients with anemia that developed on the background of chronic heart failure in the presence of renal dysfunction.