The goal of the research is to determine the effect of indometacin blockade of renal prostaglandins on the characteristics of renal function in immature rats with sublimate nephropathy under the 3% solution of sodium chloride loading.
Materials and methods. In experiments on 40 white non-linear immature (1-month old) male rats the estimation of indices of renal function with sublimate nephropathy at loading by 3 % sodium chloride solution in volume of 5% of the body weight under conditions of blocade of renal prostaglandins productions with indomethacin has shown inhibition of diuresis, decrease of sign of the syndrome of sodium ions loss with urine against the background of hypernatremia. Disorders of glomerular-calcic balance were characterized by the loss of positive correlative dependences of relative reabsorption of water with glomerular filtration, filtrative fraction and absolute reabsorption of sodium ions. It has been established that under the condition of 3% solution of sodium chloride loading in case of sublimate nephropathy in mature rats, the polyuric form of acute renal failure develops being conditioned by highest mobilization of the compensatory abilities of prostaglandin E2, a vasodilator of afferent kidney arteriole and a factor having natriuretic effect in relation to water diuresis order in which the oliguric form of acute renal failure takes place. The block of kidney prostaglandins by indomethacin under such conditions leads to the renal vasospasm and the development of oliguria. At the moment, the analysis of the effect of kidney prostaglandins block by indomethacin on the characteristics of renal functions in immature rats with sublimate nephropathy under the 3% solution of sodium chloride loading has practically been not carried out.
Results. The defined changes in glomerular-tubular balance in immature rats with sublimate nephropathy under the 3% solution of sodium chloride loading to the extent of 5% of body mass under the condition of blocking the production of renal prostaglandins by indomethacin with the loss of positive correlation dependence of the relative water reabsorption on glomerular filtration, filtration fraction and absolute reabsorption of sodium ions, prove the effect of the prostaglandins on the above given processes in immature rats. The decrease of the compensatory abilities as to the development of the syndrome of sodium ions loss in immature rats in experiment leads to the disorders of sodium homeostasis and to the development of hypernatremia.