Background. The actual task of clinical biochemistry is a study of natural origin preparations influence on activity of enzymes which play an important role in metabolism.
The aim of this research is study of aminotransferases activity in rats when using probiotic microorganisms in the diet, which are immobilized on a carbohydrate-rich carriers of probiotic microorganoisms.
Methods. There were used generally accepted methods of biochemical researches.
Results. After feeding during three weeks there were not found substantial distinctions in the levels of general lipids, cholesterol of liver and cholesterol of blood. After three months feeding content of general lipids in the liver had an insignificant tendency to decline. Animals have different values of activity of the enzymic systems of Krebs cycle and differ on the state of oxidant and antioxidant systems. The degree of distinctions depends on the kind of bioactive substance which was intaken in the diet. It was determined the activity of aminotransferases in the liver and blood of rats with diabetes mellitus and hepatitis when using in the diets of microbial probiotics, which are immobilized on high carbohydrate preparations. It was found that with alloxan diabetes and hepatitis aminotransferases activity changes as a result of extreme stress.
Conclusions. Introduction of microbial probiotic preparations prevents adverse changes and helps to normalize ratio of aminotransferases in blood and liver.