RENAL EXCRETORY FUNCTION DISORDERS IN PATIENTS WITH PULMONARY TUBERCULOSIS WITH DIFFERENT GENOTYPES GSTM1, GSTT1 AND NAT2

The work confirmed that the number of patients with pulmonary tuberculosis with microalbuminuria disorder is significantly higher (p<0.05) than the number of patients with high levels of urine general protein. NAT2 heterozygous, NAT2 homozygous, del GSTM1, del GSTT1 genotypes and the presence of allele NAT2*2*5 are associated with the renal excretory function disorder under the influence of toxic anti-TB drugs. In patients with GSTT1 gene deletion 100% incidence of renal excretory function disorders is at the prehospital stage.