Aim of this study was to investigate effect of ММР1-1607insG, VEGFA/C634G and COL2A1/6846C>A gene polymorphisms on adhesion formation after surgery.
132 patients with advanced pelvic adhesions after operations on abdominal or pelvic organs were selected for study.
Pelvic adhesion of stage I was found in 29 (21,9%), II — 40 (30.3%), III — in 34 (25.8%), IV — in 29 (21.9%) cases. Adhesions severity was not dependant on the type of surgical access (laparoscopy or laparotomy). In patients with stage III–IV adhesions 19 (30.2%) patients had a history of endoscopic surgery. Among patients with stage I–II 16 (23.2%) patients underwent laparotomy. Presence of 2G allele in the heterozygous form MMР1-1607insG was found in 126 (95.4%) patients with pelvic adhesions. 54 (40.9%) patients were found to be carriers of mutant alleles of the gene COL2A1/6846C>A. Combination of polymorphic genes MMР1-1607insG and COL2A1/6846C>A occurred in 41 (31.1%) cases. The combination of MMР1-1607insG, COL2A1/6846C>A and VEGFA/C634G polymorphisms was found in 14 (10.6%) patients with stage I adhesions.
Detection of heterozygous polymorphism — 1607insG of gene MMP1 in infertile patients indicates a high probability of adhesion formation, the relative risk of the presence of adhesions.
Presence of G-634 VEGF gene polymorphism was found in 48 (36.4%) patients with pelvic adhesive process.
Negative correlation found between the presence of VEGF gene polymorphism and adhesive process. This may indicate that presence of mutant allele G-634 of VEGF is responsible for prevention of adhesion formation.