ANTICONVULSANT AND ANTIDEPRESSANT ACTIVITY OF NEW COMPLEXES OF SnCl4 WITH SALICYLOYLHYDRAZONES OF BENZALDEHYDE AND 4-BROMBENZALDEHYDE BY ORAL ADMINISTRATION

This work is devoted to the study of antidepressant and anticonvulsant activity of new complex compounds based on tin chloride (IV) with salicyloylhydrazones benzaldehyde and 4-brombenzaldehyde by oral administration. The data show that both compounds have high antidepressant activity over 48 hours using Porsolt method. One hour after administration of both complexes, completely eliminating the immobility of animals compared with controls. Antidepressant activity of complex II is more pronounced (7% of control values) by administering to 4-position of benzaldehyde bromine atom. Data on the anticonvulsant effect of the new compounds by antagonism with pentylenetetrazole indicate about their prolonged action within 48 hours, the maximum effect was recorded 3 hours after their oral administration. For complex I data DCTC (clonic-tonic ceizures) and DTE (clonic-tonic extension) were 152 and 158%, for complex II — 170 and 190% correspondingly. Thus, the new complex compounds of SnCl4 with salicyloylhydrazones benzaldehyde and 4-brombenzaldehyde has anticonvulsant and high antidepressant effects. The introduction of bromine in benzaldehyde position 4 strengthens both duration of effect and the effect itself. These compounds are promising for further pharmacological researching.