The actuality of the problem is associated with the fact that cancer of endometrium is connected with pathology of the thyroid gland and it takes the fourth place among oncological tumors of women (after breast cancer, cancer of the lungs and large intestine). This type of cancer is 20% of all tumors of women’s genitals. The aim of investigation was to assess the influence of hypo- and hyperthyroid state on the tumor process under experimental conditions (at the example of Guérin’s carcinoma).
The experiment was performed on female Wistar rats weighing 160–180 g, which were divided into three groups: control group, animals with simulated hyperthyroid state and animals with simulated hypothyroid state. In 7 days after inoculation of tumor suspension we measured the orthogonal dimensions of the tumor, calculated its volume, and after removal of animals from the experiment performed microscopic examination of the samples of tumor and uterine body.
There was demonstrated that inhibition of Guérin’s carcinoma growth is 26% of control values for hyperthyroid state and 12% — for hypothyroid state. Induced experimental hyper- and hypothyroid states contribute to progression of Guérin’s carcinoma, which was followed with decreased nuclear-cytoplasmatic ratio and increased frequency of atypical mitosis. There is discussed the role of thyroid state in the determination of the dynamics of tumors growth.